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The Blockchain Wallet API provides a simple interface Merchants can use to programmatically interact with their wallet.To use this API, you will need to run small local service which be responsible for managing your Blockchain Wallet.Your application interacts with this service locally via HTTP API calls.Click here for complete setup instructions on GitHub.Payment Methods Connect with over 150 payment methods globally to reach users from 192 countries.check Payment Methods Instantly start selling digital goods and servicesin more than 200 countries Take advantage of being a Paymentwall merchant,advertiser, referral or affiliate Gain access to tools for fraud management, analytics and advanced reporting Please update to the more recent one.Stark Lab Deciphering the transcriptional cis-regulatory code Home Research Journal Club Members Events Publications Data Vacancies Meet Us Contact Alexander Stark Education 2004 PhD in Bioinformatics, EMBL Heidelberg & University of Cologne, Germany 2000 M.Sc in Biochemistry (German Diplom), University of Tübingen, Germany Positions 2008 - Present Group-leader, Research Institute of Molecular Pathology (IMP), Vienna, Austria 2005 - 2008 Postdoctoral Fellow, Kellis & Lander Groups, The Broad Institute of MIT and Harvard and CSAIL MIT, Cambridge, USA 2001 - 2005 PhD Student & Postdoc, Russell Group, EMBL, Heidelberg, Germany Thesis: "Functional Sites in Structure and Sequence - Protein Active Sites and microRNA Target Recognition" 2000 - 2001 Diploma Student & Research Assistant, Schuster Group, Friedrich-Miescher-Laboratory, Tübingen, Germany Thesis: "The Novel GTP-binding Protein dNOG is involved in the Synaptic Plasticity of Drosophila Neuromuscular Junctions" Honours & Awards Co-founder of Junior European Drosophila Investigators 2012 Embo Young Investigators Award 2009 European Research Council (ERC) Starting Grant (Regulatory Genomics in Drosophila) 2005 Postdoctoral Fellowship of the Human Frontiers Science Program (HFSP) 2005 Postdoctoral Fellowship of the Schering AG 2005 EMBO Postdoctoral Fellowship 1997 Fellow of the German Merit Foundation (Studienstiftung des deutschen Volkes) Funding 2010 Special Research Program (SFB) RNA-Regulation of the Transcriptome (with Julius Brennecke; Speaker: Renee Schröder) 2009 European Research Council (ERC) Starting Grant (Regulatory Genomics in Drosophila) 2009 GEN-AU BIN III (Cis-regulatory motifs; with Maria Novatchkova; Coordinator: Zlatko Trajanoski) 2009 WWTF Life Sciences Call 2009 (Molecular Mechanisms of Memory Formation: Targets of Drosophila Orb2; with Krystyna Keleman) Publications 2014 2013 2012 2011 §§ 2010 Karginov, FV., Cheloufi, S., Chong, MM., Stark, A., Smith, AD., Hannon, GJ.

Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases.(abstract) Murchison, EP., Tovar, C., Hsu, A., Bender, HS., Kheradpour, P., Rebbeck, CA., Obendorf, D., Conlan, C., Bahlo, M., Blizzard, CA., Pyecroft, S., Kreiss, A., Kellis, M., Stark, A., Harkins, TT., Marshall Graves, JA., Woods, GM., Hannon, GJ., Papenfuss, AT.The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer.(abstract) Schnorrer, F., Schönbauer, C., Langer, CC., Dietzl, G., Novatchkova, M., Schernhuber, K., Fellner, M., Azaryan, A., Radolf, M., Stark, A., Keleman, K., Dickson, BJ.bitcoin mining outletSystematic genetic analysis of muscle morphogenesis and function in Drosophila.bitcoin chart ph(abstract) Zeitlinger, J., Stark, A.bitcoin etf explained

Developmental gene regulation in the era of genomics.(abstract) Zheng, K., Xiol, J., Reuter, M., Eckardt, S., Leu, NA., McLaughlin, KJ., Stark, A., Sachidanandam, R., Pillai, RS., Wang, PJ.Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.Proc Natl Acad Sci U S A.(abstract) 2009 Heintzman, ND., Hon, GC., Hawkins, RD., Kheradpour, P., Stark, A., Harp, LF., Ye, Z., Lee, LK., Stuart, RK., Ching, CW., Ching, KA., Antosiewicz-Bourget, JE., Liu, H., Zhang, X., Green, RD., Lobanenkov, VV., Stewart, R., Thomson, JA., Crawford, GE., Kellis, M., Ren, B.bitcoin double shaHistone modifications at human enhancers reflect global cell-type-specific gene expression.ethereum decline(abstract) Malone, CD., Brennecke, J., Dus, M., Stark, A., McCombie, WR., Sachidanandam, R., Hannon, GJ.litecoin difficulty went up

Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary.(abstract) Meireles-Filho, AC., Stark, A.Comparative genomics of gene regulation-conservation and divergence of cis-regulatory information.Curr Opin Genet Dev.(abstract) Petsalaki, E., Stark, A., García-Urdiales, E., Russell, RB.Accurate prediction of peptide binding sites on protein surfaces.(abstract) Reuter, M., Chuma, S., Tanaka, T., Franz, T., Stark, A., Pillai, RS.Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile.Nat Struct Mol Biol.(abstract) Shkumatava, A., Stark, A., Sive, H., Bartel, DP.Coherent but overlapping expression of microRNAs and their targets during vertebrate development.(abstract) Shoji, M., Tanaka, T., Hosokawa, M., Reuter, M., Stark, A., Kato, Y., Kondoh, G., Okawa, K., Chujo, T., Suzuki, T., Hata, K., Martin, SL., Noce, T., Kuramochi-Miyagawa, S., Nakano, T., Sasaki, H., Pillai, RS., Nakatsuji, N., Chuma, S.

The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.Learning the transcriptional regulatory code.(abstract) 2008 Brennecke, J., Malone, CD., Aravin, AA., Sachidanandam, R., Stark, A., Hannon, GJ.An epigenetic role for maternally inherited piRNAs in transposon silencing.(abstract) Bushati, N., Stark, A., Brennecke, J., Cohen, SM.Temporal reciprocity of miRNAs and their targets during the maternal-to-zygotic transition in Drosophila.(abstract) Czech, B., Malone, CD., Zhou, R., Stark, A., Schlingeheyde, C., Dus, M., Perrimon, N., Kellis, M., Wohlschlegel, JA., Sachidanandam, R., Hannon, GJ., Brennecke, J. (2008).An endogenous small interfering RNA pathway in Drosophila.(abstract) Murchison, EP., Kheradpour, P., Sachidanandam, R., Smith, C., Hodges, E., Xuan, Z., Kellis, M., Grützner, F., Stark, A., Hannon, GJ.Conservation of small RNA pathways in platypus.(abstract) Stark, A., Bushati, N., Jan, CH., Kheradpour, P., Hodges, E., Brennecke, J., Bartel, DP., Cohen, SM., Kellis, M. (2008).

A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands.(abstract) Warren, WC., Hillier, LW., Marshall Graves, JA., Birney, E., Ponting, CP., Grützner, F., Belov, K., Miller, W., Clarke, L., Chinwalla, AT., Yang, SP., Heger, A., Locke, DP., Miethke, P., Waters, PD., Veyrunes, F., Fulton, L., Fulton, B., Graves, T., Wallis, J., Puente, XS., López-Otín, C., Ordóñez, GR., Eichler, EE., Chen, L., Cheng, Z., Deakin, JE., Alsop, A., Thompson, K., Kirby, P., Papenfuss, AT., Wakefield, MJ., Olender, T., Lancet, D., Huttley, GA., Smit, AF., Pask, A., Temple-Smith, P., Batzer, MA., Walker, JA., Konkel, MK., Harris, RS., Whittington, CM., Wong, ES., Gemmell, NJ., Buschiazzo, E., Vargas Jentzsch, IM., Merkel, A., Schmitz, J., Zemann, A., Churakov, G., Kriegs, JO., Brosius, J., Murchison, EP., Sachidanandam, R., Smith, C., Hannon, GJ., Tsend-Ayush, E., McMillan, D., Attenborough, R., Rens, W., Ferguson-Smith, M., Lefèvre, CM., Sharp, JA., Nicholas, KR., Ray, DA., Kube, M., Reinhardt, R., Pringle, TH., Taylor, J., Jones, RC., Nixon, B., Dacheux, JL., Niwa, H., Sekita, Y., Huang, X., Stark, A., Kheradpour, P., Kellis, M., Flicek, P., Chen, Y., Webber, C., Hardison, R., Nelson, J., Hallsworth-Pepin, K., Delehaunty, K., Markovic, C., Minx, P., Feng, Y., Kremitzki, C., Mitreva, M., Glasscock, J., Wylie, T., Wohldmann, P., Thiru, P., Nhan, MN., Pohl, CS., Smith, SM., Hou, S., Nefedov, M., de Jong, PJ., Renfree, MB., Mardis, ER., Wilson, RK.

Genome analysis of the platypus reveals unique signatures of evolution.(abstract) 2007 Brennecke, J., Aravin, AA., Stark, A., Dus, M., Kellis, M., Sachidanandam, R., Hannon, GJ.Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.(abstract) Kheradpour, P., Stark, A., Roy, S., Kellis, M. (2007).Reliable prediction of regulator targets using 12 Drosophila genomes.(abstract) Ruby, JG., Stark, A., Johnston, WK., Kellis, M., Bartel, DP., Lai, EC.Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs.(abstract) Stark, A., Kheradpour, P., Parts, L., Brennecke, J., Hodges, E., Hannon, GJ., Kellis, M. (2007).Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes.(abstract) Stark, A., Lin, MF., Kheradpour, P., Pedersen, JS., Parts, L., Carlson, JW., Crosby, MA., Rasmussen, MD., Roy, S., Deoras, AN., Ruby, JG., Brennecke, J., Hodges, E., Hinrichs, AS., Caspi, A., Paten, B., Park, SW., Han, MV., Maeder, ML., Polansky, BJ., Robson, BE., Aerts, S., van Helden, J., Hassan, B., Gilbert, DG., Eastman, DA., Rice, M., Weir, M., Hahn, MW., Park, Y., Dewey, CN., Pachter, L., Kent, WJ., Haussler, D., Lai, EC., Bartel, DP., Hannon, GJ., Kaufman, TC., Eisen, MB., Clark, AG., Smith, D., Celniker, SE., Gelbart, WM., Kellis, M. (2007).

Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures.(abstract) Zeitlinger, J., Stark, A., Kellis, M., Hong, JW., Nechaev, S., Adelman, K., Levine, M., Young, RA.RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo.(abstract) Zeitlinger, J., Zinzen, RP., Stark, A., Kellis, M., Zhang, H., Young, RA., Levine, M. (2007).Whole-genome ChIP-chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryo.(abstract) 2006 Behm-Ansmant, I., Rehwinkel, J., Doerks, T., Stark, A., Bork, P., Izaurralde, E.mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes.(abstract) Cohen, SM., Brennecke, J., Stark, A.Denoising feedback loops by thresholding--a new role for microRNAs.(abstract) Rehwinkel, J., Natalin, P., Stark, A., Brennecke, J., Cohen, SM., Izaurralde, E.Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster.

(abstract) 2005 Brennecke, J., Stark, A., Cohen, SM.Not miR-ly muscular: microRNAs and muscle development.(abstract) Brennecke, J., Stark, A., Russell, RB., Cohen, SM.Principles of microRNA-target recognition.(abstract) Neduva, V., Linding, R., Su-Angrand, I., Stark, A., de Masi, F., Gibson, TJ., Lewis, J., Serrano, L., Russell, RB.Systematic discovery of new recognition peptides mediating protein interaction networks.(abstract) Stark, A., Brennecke, J., Bushati, N., Russell, RB., Cohen, SM.Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution.(abstract) 2004 Stark, A., Shkumatov, A., Russell, RB.Finding functional sites in structural genomics proteins.(abstract) 2003 Aloy, P., Ceulemans, H., Stark, A., Russell, RB.The relationship between sequence and interaction divergence in proteins.(abstract) Aloy, P., Stark, A., Hadley, C., Russell, RB.Predictions without templates: new folds, secondary structure, and contacts in CASP5.

(abstract) Brennecke, J., Hipfner, DR., Stark, A., Russell, RB., Cohen, SM.bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila.(abstract) Lorentzen, E., Pohl, E., Zwart, P., Stark, A., Russell, RB., Knura, T., Hensel, R., Siebers, B.Crystal structure of an archaeal class I aldolase and the evolution of (betaalpha)8 barrel proteins.(abstract) Stark, A., Brennecke, J., Russell, RB., Cohen, SM.Identification of Drosophila MicroRNA targets.(abstract) Stark, A., Russell, RB.Annotation in three dimensions.PINTS: Patterns in Non-homologous Tertiary Structures.(abstract) Stark, A., Sunyaev, S., Russell, RB.A model for statistical significance of local similarities in structure.(abstract) 2002 Métivier, R., Stark, A., Flouriot, G., Hübner, MR., Brand, H., Penot, G., Manu, D., Denger, S., Reid, G., Kos, M., Russell, RB., Kah, O., Pakdel, F., Gannon, F. (2002).A dynamic structural model for estrogen receptor-alpha activation by ligands, emphasizing the role of interactions between distant A and E domains.